Dissolve-E: AWMF Guideline Registry
0.2.0 - ci-build

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## CodeSystem: SIGN Level of Evidence

Official URL: http://fhir.awmf.org/awmf.ig/CodeSystem/cs-sign-level-of-evidence | Version: 0.2.0
Active as of 2026-01-29 | Computable Name: SIGNLevelOfEvidence

CodeSystem representing the Scottish Intercollegiate Guidelines Network (SIGN) Levels of Evidence.

This Code system is referenced in the content logical definition of the following value sets:

- SIGNLevelOfEvidenceVS

This case-insensitive code system `http://fhir.awmf.org/awmf.ig/CodeSystem/cs-sign-level-of-evidence` defines the following codes:

Code | Display | Definition | Deutsch (German, de)
1plusplus | 1++ | High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias. | 1++
1plus | 1+ | Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias. | 1+
1minus | 1- | Meta-analyses, systematic reviews, or RCTs with a high risk of bias. | 1-
2plusplus | 2++ | High-quality systematic reviews of case-control or cohort studies, or high-quality case-control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal. | 2++
2plus | 2+ | Well-conducted case-control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal. | 2+
2minus | 2- | Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal. | 2-
3 | 3 | Non-analytic studies, e.g., case reports, case series. | 3
4 | 4 | Expert opinion. | 4