Dissolve-E: AWMF Guideline Registry
0.2.0 - ci-build

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CodeSystem: SIGN Level of Evidence

Official URL: http://fhir.awmf.org/awmf.ig/CodeSystem/cs-sign-level-of-evidence Version: 0.2.0
Active as of 2026-01-29 Computable Name: SIGNLevelOfEvidence

CodeSystem representing the Scottish Intercollegiate Guidelines Network (SIGN) Levels of Evidence.

This Code system is referenced in the content logical definition of the following value sets:

This case-insensitive code system http://fhir.awmf.org/awmf.ig/CodeSystem/cs-sign-level-of-evidence defines the following codes:

CodeDisplayDefinitionDeutsch (German, de)
1plusplus 1++ High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias. 1++
1plus 1+ Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias. 1+
1minus 1- Meta-analyses, systematic reviews, or RCTs with a high risk of bias. 1-
2plusplus 2++ High-quality systematic reviews of case-control or cohort studies, or high-quality case-control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal. 2++
2plus 2+ Well-conducted case-control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal. 2+
2minus 2- Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal. 2-
3 3 Non-analytic studies, e.g., case reports, case series. 3
4 4 Expert opinion. 4