Dissolve-E: AWMF Guideline Registry
0.2.0 - ci-build
Dissolve-E: AWMF Guideline Registry - Local Development build (v0.2.0) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions
| Active as of 2026-01-29 |
{
"resourceType" : "CodeSystem",
"id" : "cs-sign-level-of-evidence",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem cs-sign-level-of-evidence</b></p><a name=\"cs-sign-level-of-evidence\"> </a><a name=\"hccs-sign-level-of-evidence\"> </a><p>This case-insensitive code system <code>http://fhir.awmf.org/awmf.ig/CodeSystem/cs-sign-level-of-evidence</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td><td><b>Deutsch (German, de)</b></td></tr><tr><td style=\"white-space:nowrap\">1plusplus<a name=\"cs-sign-level-of-evidence-1plusplus\"> </a></td><td>1++</td><td>High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias.</td><td>1++</td></tr><tr><td style=\"white-space:nowrap\">1plus<a name=\"cs-sign-level-of-evidence-1plus\"> </a></td><td>1+</td><td>Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias.</td><td>1+</td></tr><tr><td style=\"white-space:nowrap\">1minus<a name=\"cs-sign-level-of-evidence-1minus\"> </a></td><td>1-</td><td>Meta-analyses, systematic reviews, or RCTs with a high risk of bias.</td><td>1-</td></tr><tr><td style=\"white-space:nowrap\">2plusplus<a name=\"cs-sign-level-of-evidence-2plusplus\"> </a></td><td>2++</td><td>High-quality systematic reviews of case-control or cohort studies, or high-quality case-control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal.</td><td>2++</td></tr><tr><td style=\"white-space:nowrap\">2plus<a name=\"cs-sign-level-of-evidence-2plus\"> </a></td><td>2+</td><td>Well-conducted case-control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal.</td><td>2+</td></tr><tr><td style=\"white-space:nowrap\">2minus<a name=\"cs-sign-level-of-evidence-2minus\"> </a></td><td>2-</td><td>Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal.</td><td>2-</td></tr><tr><td style=\"white-space:nowrap\">3<a name=\"cs-sign-level-of-evidence-3\"> </a></td><td>3</td><td>Non-analytic studies, e.g., case reports, case series.</td><td>3</td></tr><tr><td style=\"white-space:nowrap\">4<a name=\"cs-sign-level-of-evidence-4\"> </a></td><td>4</td><td>Expert opinion.</td><td>4</td></tr></table></div>"
},
"url" : "http://fhir.awmf.org/awmf.ig/CodeSystem/cs-sign-level-of-evidence",
"version" : "0.2.0",
"name" : "SIGNLevelOfEvidence",
"title" : "SIGN Level of Evidence",
"status" : "active",
"experimental" : false,
"date" : "2026-01-29T18:27:10+00:00",
"publisher" : "AWMF e.V.",
"contact" : [
{
"name" : "AWMF e.V.",
"telecom" : [
{
"system" : "url",
"value" : "https://www.awmf.org"
}
]
}
],
"description" : "CodeSystem representing the Scottish Intercollegiate Guidelines Network (SIGN) Levels of Evidence.",
"caseSensitive" : false,
"content" : "complete",
"count" : 8,
"concept" : [
{
"code" : "1plusplus",
"display" : "1++",
"definition" : "High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Hochwertige Metaanalysen, systematische Reviews von RCTs oder RCTs mit sehr niedrigem Bias-Risiko."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "1++"
}
]
},
{
"code" : "1plus",
"display" : "1+",
"definition" : "Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Gut durchgeführte Metaanalysen, systematische Reviews oder RCTs mit geringem Bias-Risiko."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "1+"
}
]
},
{
"code" : "1minus",
"display" : "1-",
"definition" : "Meta-analyses, systematic reviews, or RCTs with a high risk of bias.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Metaanalysen, systematische Reviews oder RCTs mit hohem Bias-Risiko."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "1-"
}
]
},
{
"code" : "2plusplus",
"display" : "2++",
"definition" : "High-quality systematic reviews of case-control or cohort studies, or high-quality case-control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Hochwertige systematische Reviews von Fall-Kontroll- oder Kohortenstudien oder hochwertige Fall-Kontroll- oder Kohortenstudien mit sehr niedrigem Risiko für Confounding oder Bias."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "2++"
}
]
},
{
"code" : "2plus",
"display" : "2+",
"definition" : "Well-conducted case-control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Gut durchgeführte Fall-Kontroll- oder Kohortenstudien (nicht-randomisierte Studien) mit niedrigem Risiko für Confounding oder Bias."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "2+"
}
]
},
{
"code" : "2minus",
"display" : "2-",
"definition" : "Case-control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Fall-Kontroll- oder Kohortenstudien mit hohem Risiko für Confounding oder Bias."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "2-"
}
]
},
{
"code" : "3",
"display" : "3",
"definition" : "Non-analytic studies, e.g., case reports, case series.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Nicht-analytische Studien, z. B. Fallberichte, Fallserien."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "3"
}
]
},
{
"code" : "4",
"display" : "4",
"definition" : "Expert opinion.",
"_definition" : {
"extension" : [
{
"extension" : [
{
"url" : "lang",
"valueCode" : "de"
},
{
"url" : "content",
"valueString" : "Expertenmeinung."
}
],
"url" : "http://hl7.org/fhir/StructureDefinition/translation"
}
]
},
"designation" : [
{
"language" : "de",
"value" : "4"
}
]
}
]
}